Minitab 15.1 (statistical Software) Full Version
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Eight types of preparations could predict dissolution and disintegration of a tablet in the oral cavity. They are water, water at pH 2.2, water at pH 1.2, water at pH 6, water at pH 2, water at pH 4, and water at pH 7. These results show that the dissolution profiles were more affected by the media pH and the dissolution media rather than the quantity of diammonium citrate. Hydrogen ions (H+) stimulate the dissolution of the tablet. The dissolution of a tablet is a function of the rate of drug release, media pH, and the relative amounts of H+ and OH-. These effects add up to make dissolution slower at higher pHs. The media pH controls the release of diammnonium citrate. The dissolution media puhs control the release of a drug depending on the concentration of the drug and media. Figure 2: Dissolution profiles
The mean dissolution values were calculated by comparing the dissolution values of each formulation at different pH values from 0 to 24 hr (Fig. 3). By comparing them to those of drug alone, drug loaded CSS (hydroxypropyl cellulose) and PCL (polycaprolactone) formulations, the sodium bicarbonate tablet containing its own release rate showed the fastest release and highest dissolution percentage. The second sodium bicarbonate tablet showed the slowest release and second lowest dissolution percentage. The zero-order model was applied to describe the release kinetic of DOM FDT from the three sodium bicarbonate tablets and explained the release pharmacokinetics of DOM FDT. The tablet has a release profile of zero order. The Sodium bicarbonate tablet has faster release after 2.0 hr to result in the fastest release, but the dissolution percentage was lower since dissolution rate decreases and then reached to steady state with the zero order model. It shows that prolonged release formulations might not be applicable for a faster drug release. 20-30 percent of the dissolved amount of DOM FDT was released by dissolution in PBS pH 6.0 media at 24 hr. d2c66b5586